HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04116(IDE antibody) at dilution of 1:300
IP Result of anti-IDE (IP:FNab04116, 4ug; Detection:FNab04116 1:500) with HepG2 cells lysate 1600ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab04116(IDE antibody) at dilution of 1:50
Background
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. (Microbial infection) The membrane-associated isoform acts as an entry receptor for varicella-zoster virus(VZV).